Abstarct: A honeycomb panel consists of an array of open hexagonal cells which their wallsare perpendicular to face sheets although other panel sandwichs don’t have these perpendicular walls. These structures have high flexibility per stiffness and strength per weight. Panel sandwiches, specially those, which made of Aluminum, considerably used in many engineering branches such as space, navy , overland and currently in building. Original attempt of this thesis, is modeling behaviour of honeycomb panels by ANSYS software. To validate the proposed FE models, the test results obtained from other researchers were compared with the models results and very good agreement was found. In this study, at first panel with details including the core dimensions, thickness and height of the core and face's thickness has been studied. Dimensions of panel looking at 1x3 metersmeters was considered under the uniform and concertrated loadat the center were analyzed. The constrain's ends of panel modeled hinged support , then the effect of pipe crossing along the panel's length was studied and under identical loading and constrain's compared with the conventional panel. As the results of finite element was observed, flexural properties with increasing core's height substantially increased without much change in weight. It also increases the thickness of the core and face, flexural properties increased and reduced displacement, von Mises stress and strain in the panel. Models results indicated the maximum von Mise stress and strain of the middle of panel transmitted in cutting place on pipe crossed panel.