Abstarct: Deterioration of concrete structures in marine environments, especially in Persian Gulf region is a serious problem mainly due to chloride ingress into concrete. It is generally assumed that the diffusion of chloride ions follows Fick’s second low. In this equation, Diffusion coefficient is a quantified representative of different effective parameters like water to binder ratio, silica fume content and etc. This study attempts to model the relation between diffusion coefficient and various parameters collected from experimental works in Persian Golf by using an Adaptive Network-baxsed Fuzzy Inference Systems (ANFIS). The predicted results were satisfactory and by comparing the obtained rules and results, significant conclusion can be drawn to illustrate the behavior of a natural system and evaluate the general trend in a system such as chloride diffusion. Therefore it can assist researchers in finding out the effect of different parameters in chloride diffusion.