Abstarct: Miangran wetland which is an essential source of water for groundwater recharge, agriculture uses and living environment for rare birds in Khuzestan province, is affected by different contamination sources like municipal and agricultural wast water. In this research the affects of the the pollution sources on wetland quality was studied.Twenty nine water samples (24 samples from wetland body and 5 other from the inputs) were collected and major ions, nitrates, phosphates and heavy mextals were measured. The Results show that water-type of the input are Ca–HCO3 and Mg–HCO3. The concentration of Nitrate is less than the WHO standards. Phosphate concentration is more than eutrophication control limit, could be a cause for wetland eutrophication. Concentration of Cd, pb, As, Zn, Ni, Cr, Fe and Al for the all inputs are more than WHO standards. The Concentration of toxic elements of As and Cd are also more than FAO permissible values. The Maximum contaminations load is related to input I2 (Izeh wast water canal) in which As, Cd and Zn show high concentrations. The qualitative assessments of Miangran wetland show that most of the sample are of a Ca–HCO3 and Mg–HCO3 water-type. Phosphate concentrationin The all samples is higher than the eutrophication control limit, confirms eutrophication conditions are dominant. In compared with WHO standards, the wetland water samples are contaminated with Cd, pb, As, Zn, Ni, Cr, Fe and Al. Concentration As and Cd are more than The FAO standard for irrigation uses. Spatial change of these element show that more contamination is observed at South and the North-West parts of the wetland where the municipal wast water (I2) and surface run-off from bordering village (I6) are discharged to the wetland, Respectively. All the wetland water samples have mextal index higher than the threshold limit which is greatly related to high concentration of As and Cd.