Abstarct: 4H-Pyrans and 4H-chromens have a broad range of applications. They have shown different biological and pharmacological activities such as antitumor, antibacterial, anti-HIV, antifungal, and anti-inflammatory. In this study, 2-amino-5-ethoxy carbonyl-4-aryl-3-cyano-6-methyl-4H-pyran derivatives were synthesized from the multicomponent reaction of an aldehyde, malononitrile and ethyl acetoacetate, in the presence of K2CO3 as a baxse at 70 °C in MDW. Moreover, 2-amino-3-cyano-7-hydroxy-4-aryl-4H-chromene derivatives were synthesized from the multicomponent reaction of an aldehyde, malononitrile and resorcinol, in the presence of K2CO3 as a baxse at 70 °C in MDW. This new procedure offers numerous advantages, including high reaction yield, cleaner reaction profile, low costs, environmentally benign, and easy workup.