Abstarct: Abstract In this study, Ti3C2Tₓ/ZIF-67 nanocomposite was synthesized and evaluated as an efficient adsorbent for the removal of colored pollutants from textile wastewater. The physical and chemical properties of the synthesized adsorbent were investigated using various analyses such as FESEM, EDS, FTIR, XRD, BET and zeta potential. The results showed that the combination of two-dimensional Ti3C2Tₓ MXene sheets with ZIF-67 mextal-organic frxamework resulted in the creation of a porous structure with high specific surface area and active functional groups that play a key role in the adsorption process. Comparison of the performance of the nanocomposite with its precursor’s materials (ZIF-67 and Ti3C2Tₓ) showed a significant improvement in the adsorption capacity and removal efficiency of the cationic dye Natural Red, which is due to the synergistic effect between the properties of these two materials. The study of the effective operational parameters on the adsorption process showed that the highest removal efficiency of NR dye under optimal conditions of pH 3, initial concentration of 10 mg/L, adsorbent amount of 0.5 g/L and contact time of 30 minutes reached 92.8% with the maximum adsorption capacity of 70.38 mg/g. Also, the results obtained from investigating the coexisting of interfering compounds in wastewater containing cationic dye indicated a decrease in adsorption capacity in the presence of different anions with the following ranking: CO32-> SO42-> Cl-. Adsorption isotherm studies showed that the adsorption process followed the Langmuir isotherm model with a correlation coefficient of R²=0.998. This condition confirms the homogeneity of the adsorbent surface in terms of active adsorption sites and the single-laxyer nature of the pollutant adsorption process on the adsorbent. Also, the study of adsorption kinetics confirmed that the experimental data were in better agreement with the pseudo-second-order model with R²=0.992. The Ti3C2Tₓ/ZIF-67 nanocomposite showed high efficiency in removing NR dye from aqueous medium by utilizing various mechanisms including hydrogen bonding, physical trapping, and π-π interactions. These features make this nanocomposite a suitable option for the treatment of industrial wastewater containing cationic dyes.