Abstarct: In designing and developing a flotation circuit, it is imperative to know the characteristics and behavior of the ore in the process of flotation. Investigating the behavior of ore flotation by performing batch experiments is carried out. By performing these experiments, the effect of parameters such as concentration and type of chemicals on ore behavior in the flotation process is investigated. Also, the components of flotation capability are modeled in different units of the circuit. The most oxidized lead mineral is cerusite, and later it is anglesite, which in most mineral processing plant, the flotation circuit belongs to the cerusite. The processing method is such that, in first cerusite sulfided by sodium sulfide or sodium hydro-sulfide, and then floated by xanthates. Sodium silicate is used as a particle level cleaner, zinc sulfate is used as a depression of sphalerite(if available), and sodium cyanide as a depression of pyrite(if available). In this study, a low-grade oxidized lead ore system ore has been considered to improve its recovery. First, the properties of oxidized ore were investigated using XRF and XRD methods, and then the effect of the collectors combination of potassium emyl-xanthate, sodium ethyl-xanthate, and mercaptan collectors with flotation experiments was performed, then the ratio of 50%, 30% and 20% as the best combination of three collectors was chosen. The effect of chemical agents as combinational collector; sodium sulfide, pH and frother agent was investigated using the response surface design test to improve recovery of lead oxide minerals. In the range of parameters studied, recovery of lead oxide minerals in lead concentrate was 89.7%. This amount was recovered at pH = 8, the amount of frother agent is obtained 40 g/t, sodium sulfide content 1500 g/t, and the combinational collector content of 150 g/t.