Abstarct: Extraction behavior of copper from real pregnant sulphate leach solution obtained from the heap leaching stage of copper oxide ore of Chahmousa mine was investigated using Chemorex CP-150 in kerosene. In solvent extraction experiments, various parameters including pH, temperature, organic solvent concentration, organic to aqueous phase ratio and time were investigated. Comparative study was also carried out on the extraction capability of Cu(II) using other solvents including D2EHPA and Cyanex 272. Chemorex CP-150 demonstrated an effective and selective extraction performance of copper with the amount of extracted Fe less than 15%. Also, the results indicated that more than 66.4 and 96.99% Cu transferred to organic phase in a single extraction stage using 15% (v/v) Chemorex CP-150 under condition of 25 °C, pH 2.5, and contact time of 20 min at A:O phase ratios of 1:1 and 1:4, respectively. The McCabe–Thiele diagram was applied to estimate the number of theoretical stages of extraction, and exhibited that two extraction stages were required to achieve the maximum amount of Cu at 1:1 phase ratio under optimal conditions. The process mechanism was studied baxsed on thermodynamic data and it proved that the extraction process is slightly endothermic (ΔH=7.62 kJ/mol) indicating the relatively smaller heat effects on the formation of a single complex species (CuR2). In addition, the influence of binary mixtures of D2EHPA, Cyanex 272 and CP-150 was studied on the extraction percentage of copper and iron. The results demonstrated that D2EHPA, Cyanex 272 have the high value of iron extraction and have no copper extraction ability and meanwhile the binary mixtures of these solvents had the antagonistic effects. The stripping of copper from the loaded organic phase was also conducted and it was found that ~99.38% copper could be recovered using 165 g/L H2SO4 at 2:1 A:O phase ratio after 5 minutes stripping.