Abstarct: The aim of this study was to investigate the parameters affecting the flotation concentrate plant integrated circuit is Sangan. Sulfur content in the concentrate plant, exceeded (0.2%) for use as pellet plants. The flotation process parameters optimize, in order to achieve maximum reduction of sulfur content in iron concentrate. After determine the optimum conditions for plant flotation circuit parameters, a number of tests were designed and most effective parameters include the concentration of the collector, frother concentration, pH, solid percent were determined. Other parameters such as preparation time, frothing time, stirring speed, etc. were considered fixed in all experiments. 26 tested design using software DX7 in the experimental, to determine changes in response to changes in these factors at two levels and also acts as the central point of each parameter were factory conditions. Analysis of the results show that the frother concentration (MIBC), pH, collector concentration (SIPX) and solid percent have the greatest impact on reducing sulfur. Using the factors and analysis, software was predicted appropriate operating conditions to achieve the maximum reduction of sulfur grade concentrate, the in the laboratory. The application of collector 90 ppm, MIBC 65 ppm, pH = 8.3 and solid 28%, sulfur content in the rougher stage of 0.65 input feed percent to 0.254 percent (61.53 percent reduction sulfur) and then cleaner stage of tests to o.198 percent (total 69.54 percent sulfur) was reduced. Finally, the optimal conditions in the flotation circuit and acts in the best condition of 0.57 percent sulfur content input feed flotation circuit to 0.22 percent (61.9 percent) was reduced.