Abstarct: Growing of the population increases the use of energy and therefore the use of renewable energy as the best replacement for fossil fuel. On the other hand, due to running out of fossil energy resources, natural and environmental hazards and high costs, switching to clean energy seems logic. Different geological and exploration techniques are required to be employed to locate the best targets for geothermal as the future energy resources. According to the situation of Iran in geothermal belt, there are different geothermal fields. This confirmed by previous studies of potential geothermal resources in some parts of iran. The East Azerbaijan Province is considered as a target, according to the young volcano and hot springs where the temperature will exceed 50 ˚C. In this study, the geochemical behavior of some of elements such as REE, As, Cl, B, Ge, Ga and Hg in water samples, soil and rock in geothermal areas has been investigated and compared with that of other parts of the world. The Ghare Aghaj area can be considered as an important geothermal potential with a large argillic alteration as the indication of hydrothermal activities, in addition to high concentrations of Hg and As in soil samples and As in water’s Manshage-Charoimagh. Kaleibar region is the next target due to high concentrations of Mo and Ga in water sample of spring AbishAhmad and high concentration of Hg in soil samples. Bostanabad and Lighavan areas can also be important, due to the high concentrations of As, B, Sr and Ge at their spring water samples, and Hg content in soil samples around their springs. Mianeh and Hashtrood area show higher concentrations of more trace elements, that can be associated with deep hydrothermal systems. Geothermometry studies revealed GhareAghaj as the hottest and Kaleibar region as the lowest reservoirs in eastern Azerbijan province.