Abstarct: Globe Valve is one of the most important control valves in the industry. This valve is made in different sizes and for different applications. One of the destructive phenomena that happen in this valve is cavitation. Cavitation causes vibration, noise, and corrosion inside the valve, so the working life of the valve is reduced. For this reason, some solutions have been proposed to control and prevent this phenomenon in the valves. One of the effective ways to control the cavitation is to install a cage inside the valve. The cages are perforated or grooved mextal plates that are installed inside the valve to reduce the cavitation. Many factors are affecting the performance of these cages, such as: shape, diameter, and arrangement of the holes, and the thickness of the cage body. some articles and researches have examined the mentioned factors. In this study, the effect of oblique holes is investigated. As a result, the cages are designed with radial holes, oblique holes facing downwards, and oblique holes facing upwards, and then numerical simulations are performed to evaluate their performance. The best model is selected by considering some parameters such as velocity vectors, cavitation number, and the intensity and location of the cavitation. By analyzing the mentioned parameters, it was observed that the cage with oblique holes facing downwards has a better performance in controlling and reducing the cavitation. In fact, in this model, the internal components of the valve will be safer than the other two models.