Abstarct: Microfluids have many applications in modern sciences such as medicine and medical engineering. Creating and directing droplets in small dimensions has many advantages in addition to engineering in the field of medicine and treatment. In the production of drops, two types of systems are usually used to inject fluids; 1- Using pressure regulation in fluid flow lines; 2- Syringe pump. Flow generation using a syringe pump is one of the most common systems in the production of microparticles. There has been a lot of research in this area today, but a limited number of them have controlled droplet size and changed it online. In this research, to create the flow and change it actively, a syringe pump has been designed and in its construction, a DC motor with suitable speed and torque and L298N module has been used. For active control of this system, an Arduino Mega 2560 board is used as a processor system, and for measuring the droplet diameter, a high-speed digital microscope with a fast image processing algorithm is used. Feedforward-feedback algorithm has been used to increase the response speed of the control system. For this purpose, an inverse model using fuzzy-neural networks is used, the input of which is the diameter of the drop and the output of which is the flow required to reach that diameter. This model has been created using experimental data and fuzzy-neural network training. Then, to overcome the uncertainties and use the benefits of the feedback loop to overcome the perturbations and uncertainties, PID algorithms and sliding modes due to their resistance to uncertainties and perturbations are used to actively control the diameter of the micro-droplets. The results of implementing algorithms designed for three droplet diameters of 82, 90 and 100 μm, show the effectiveness of the proposed methods and the proper performance of the feedback loop in adjusting the droplet diameter. Histogram diagrams have been used to evaluate the performance of the feedback loop in each case. Of course, there are fluctuations in system behavior that can be due to vibrations in the syringe pump motor, flexibility of connections.