Abstarct: Abstract Today, in many countries of the world, the construction industry has taken a special form, and Iran is no exception. With the increase in population and the limitation of urban land on the one hand, and the advancement of science and the change in people's lifestyle on the other, the construction industry has turned to high-rise construction. Iran is located on the seismically active Alp-Himalayan belt and is considered one of the most earthquake-prone countries in the world, as evidenced by its historical record of seismic events. Additionally, the issue of repeated earthquakes, particularly following the devastating earthquake in Turkey in 2023, has heightened the importance of designing buildings. This is because a building must maintain its stability and integrity for a certain period after experiencing multiple seismic events, in order to ensure the life safety performance that is the minimum requirement for residential structures.The devastating 2023 Turkey earthquake and widespread structural damage caused by repeated earthquakes have highlighted the urgent need to evaluate the seismic performance of structures under such phenomena. With the increasing construction of tall buildings in seismically active regions, assessing their behavior under repeated seismic events is essential. This study probabilistically investigates the seismic performance of a 35-story reinforced concrete building with a special moment-resisting frxame and shear wall system, considered as a benchmark model in a high seismicity region. The structure was designed according to the 4th edition of the Iranian seismic code (Standard No. 2800) using ETABS software and subsequently modeled in PERFORM-3D for nonlinear analyses. Nonlinear dynamic time-history analyses using a endurance time method approach were conducted under repeated ground motions, employing far-field seismic records as outlined in FEMA-P695. The endurance time method is a time history dynamic analysis approach that exposes the structure to a series of pre-designed incremental records. This method is significantly less costly and computationally intensive compared to the Incremental Dynamic Analysis (IDA) method, while simultaneously providing more useful information. The main objective is to derive and compare fragility curves for the building subjected to single and repeated earthquake excitations. Fragility curves were developed baxsed on the initiation of the first plastic hinge as an engineering demand parameter, covering damage states from slight to collapse. Results indicate that the seismic response under repeated earthquakes differs significantly from single-event conditions, especially at moderate and severe damage levels. For instance, the increase in the median fragility at the moderate damage level after the second earthquake along the x-direction was reported to be 24% and 38% for the DBE and MCE hazard levels, respectively, and along the y-direction, it was reported to be 27% and 37%, respectively. Also, the median fragility increase at the level of extensive damage after the second earthquake along the x-direction was reported to be 28% and 42% for the DBE and MCE hazard levels, respectively, and along the y-direction, it was reported to be 30% and 42%, respectively. The findings emphasize that the recurrence of earthquakes can significantly affect the vulnerability and overall performance of structures. The results obtained from the fragility curves can serve as an effective tool for improving design standards and seismic assessment of tall buildings in earthquake-prone areas.