Abstarct: Today, increasing the concentration of drugs in the environment has become a global crisis. With the use of drugs, the active drug compounds are excreted from the body without deformation or in the form of mextabolic compounds, and appear in urban sewage systems and finally enter the environment. Adsorption is one of the methods for drugs removal, especially antibiotics. One of the most widely used types of adsorbents is mextal-organic frxameworks. These adsorbents have received much attention due to their characteristics such as high specific surface area, high volume of cavities, good stability and design capability in different methods. The aim of this study was to synthesize two structures of mextal-organic frxameworks HKUST-1 and NH2-MIL-101-(Fe) and investigate their performance in removing metronidazole antibiotic from aqueous solution. In this study Hach DR-6000 was used to measure the amount of drug adsorbed by the adsorbents. Both adsorbents were synthesized by the solvothermal method. The structure, particle size, and the other adsorbents properties were investigated using FT-IR, XRD, SEM, EDS, and BET analyzes. The results of analyzes confirmed the formation of the mentioned adsorbents. The specific surface area of HKUST-1 and NH2-MIL-101-(Fe) were measured equal to 569 m2/g and 3874 m2/g, respectively. The effects of pH, adsorbent dose, initial concentration, and contact time on the antibiotic removal process were investigated. The results showed that the percentage of antibiotic removal, first has an upward trend by increasing the initial amount of adsorbent and then reaches a constant value, which indicates a decrease in active sites on the adsorbent surface. The presence of C-N2, C-H, and C=C groups in the FT-IR results of adsorbents after adsorption proved the adsorption of metronidazole by both adsorbents. The study of adsorption kinetics showed that metronidazole adsorption was consistent with pseudo-second-order model for both adsorbents. The metronidazole adsorption isotherm also follows the Longmuir model for both adsorbents. At pH=7, the maximum adsorption capacity for HKUST-1 adsorbent was 30.14 mg/g in 20 min and for NH2-MIL-101-(Fe) adsorbent was 42.92 mg/g in 10 min. In general, it can be stated that HKUST-1 and NH2-MIL-101-(Fe) adsorbents are highly effective adsorbents for removing metronidazole antibiotic from aquatic environment.