Abstarct: Saltwater intrusion into freshwater aquifers can lead to salinization of many aquifers in Iran, particularly in provinces in the vicinity of deserts including Khorasan Razavi, in the near future. Groundwater quality changes are one of the problems that have become worrisome among water resource planners, especially in arid regions, due to the high water harvesting and reduction in nutrition. Also, more than 70 percent of Iran's aquifers, in addition to the dehydration problem, have an environmental crisis. In desert areas, the influx of saltwater fires has resulted from water withdrawal, the concentration of salts increases and causes environmental problems. Most researches on the saltwater intrusion have focused on coastal aquifers along the margins of the seas, oceans and saline lakes, and the discussion of the identification and control of the advancement of salinity, and parallel to that of salinity in the adjacent desert aquifers, is one of the issues in the country. We, therefore, call for in-depth studies of various dimensions. The specific purpose of this study is to simulate and predict saltwater intrusion in vicinity of desert aquifers using quantitative and qualitative water modeling of groundwater. The Sarakhs aquifer, one of the plains of Khorasan Razavi province, was selected as a case study. The length of the modeling period is 6 years, from which 6 years, 4 years to calibrate the model and 2 years to model validation. The model was modulated with Modflow model and qualitative model with Mt3dms and Seawat model. In the calibration of the quantitative model, the range of hydraulic conductivity changes from 10 m / day to 90 m / day and the aquifer storage factor was 0.03 to 0.21. In the sensitivity analysis of the model, we conclude that the model is sensitive to hydraulic conductivity and saturation of the aquifer. In the calibration of the qualitative model, the mean dispersion length was 40 m and the coefficient of transverse dispersion was 0.1 versus 0.1. The rate of saltwater intrusion in the quality model over the course of 6 years as well as the progress level for 20 years of forecasting was achieved.