Abstarct: Abstract Soybean (Glycine max L.) is one of the most important leguminous crops worldwide, serving as a major source of high-quality protein and oil. Its yield and seed quality are profoundly influenced by weed management strategies and tillage systems. Accordingly, a field experiment was conducted in 2021 in two locations of Golestan Province, Iran, using a strip-plot arrangement baxsed on a randomized complete block design, to evaluate the effects of different tillage systems and herbicide applications on weed control, crop growth, and yield performance of soybean. In the main plots, different tillage methods including no-tillage, reduced tillage, and conventional tillage were assigned, while various weed management treatments including hand weeding, no weeding, and different combinations of pre-emergence metribuzin and post-emergence herbicides (imazethapyr, bentazon, and clethodim) were placed in the subplots. The results indicated that the highest soil microbial basic respiration rate (0.375 mg CO₂ 100gr⁻¹ day⁻¹) occurred under no-tillage combined with hand weeding, while the lowest value was observed under conventional tillage with metribuzin application at 600 g ha⁻¹. The greatest reductions in weed density were achieved in conventional and no-tillage systems combined with metribuzin + bentazon + clethodim, as well as in no-tillage and reduced-tillage systems combined with metribuzin + imazethapyr (1000 mL ha⁻¹). Similarly, the lowest weed dry weight was recorded under metribuzin + bentazon + clethodim and metribuzin + imazethapyr (1000 mL ha⁻¹) treatments. The highest leaf area index was obtained under no-tillage combined with metribuzin + imazethapyr (1000 mL ha⁻¹), followed by no-tillage and reduced-tillage systems combined with metribuzin + bentazon + clethodim. The maximum total chlorophyll content (3.44 mg g⁻¹ fresh weight) was observed in the no-tillage treatment combined with metribuzin + bentazon + clethodim. No-tillage systems with integrated herbicide use (metribuzin + bentazon + clethodim or metribuzin + imazethapyr) significantly enhanced pod number per plant, seed number per pod, plant dry weight, biological yield, and harvest index. The highest seed yield (3129 kg ha⁻¹) was obtained under no-tillage combined with metribuzin + bentazon + clethodim, whereas the lowest seed yield (1297 kg ha⁻¹) was recorded under conventional tillage without weed control. The highest seed oil and protein contents were associated with the no-weed-control and metribuzin + bentazon + clethodim treatments, respectively. Overall, the results suggest that the adoption of no-tillage systems in combination with integrated pre- and post-emergence herbicide applications improves soil properties, enhances weed suppression, and consequently increases soybean growth and productivity.