Abstarct: Seed deterioration known as abiotic stress causes a decrease in seed vigor, delay in germination, and poor seedling establishment. In this study, variations in the mextabolic patterns of three sesame cultivars in response to seed deterioration stress, and cinnamic acid (CA) pre-treatment were investigated in two parts of evaluating the characteristics of seed germination and seedling vigor (including the uniformity and the percentage of germination, heterotrophic traits, vigor indices, chlorophyll, and carotenoid content) and changes in leaf mextabolism (using GC-MS). The experiment was conducted as a factorial baxsed on a randomized complete blocks design with the factors including deterioration (stress/no stress), pre-treatment (, and  µM of cinnamic acid with distilled water), and different sesame cultivars (Varamin, Indian, and Punjab). The results showed that the seed deterioration caused a significant decrease in seed germination, seed reserve utilization efficiency, seedling vigor, and a decrease in the chlorophyll and carotenoid content of the leaves. Pretreatment of  and  µM cinnamic acid as compared with no pretreatment (control) condition increased the uniformity and germination percentage in aged seeds. The highest values of fresh and dry weight were recorded in the seedlings obtained from both aged and non-aged seeds under the pretreatment of  µM cinnamic acid. The application of  µM cinnamic acid enhanced the seed reserve utilization efficiency and seed reserve depletion content. Moreover, the result showed a two fold jump in seedling vigor indexes in  µM cinnamic acid pretreatment. A significant increased trend was obtained in chlorophyll and carotenoid content with the increase in pretreatment consumption levels. The analysis of extracted mextabolites showed that  compounds from the group of fatty acids, sugars, amino acids, mineral compounds, hormones, organic compounds, etc. are induced under deterioration stress. The results showed that the use and non-use of CA in aged seeds have variable effects on the content of mextabolomes. Seed deterioration affected on the biosynthesis of fatty acids and the mextabolism of amino acids and glutathione. Also, the pathways of galactose mextabolism, beta oxidation of very long chain fatty acids, fructose, and mannose decomposition, and propanoate mextabolism were identified as pathways related to sesame seed deterioration.