Abstarct: According to water limitation for irrigation over time and importance of drought stress in crops such as soybean, in order to analyze the effect of foliar application of silicon and proline to create tolerance of irrigation conditions and growth improvement in soybean plant, an experiment was conducted on the farm of the faculty of agriculture of Shahrood University of Technology in Bastam in the summer of 2019, in the form of a completely randomized block design with three replications. Treatment including irrigation cycles (8, 12 and 16 days), two levels of silicon (0 and 3 mM) and three levels of proline (0, 25 and 50 mM) were applied. Factors including plant dry weight, plant height, steam diameter, number of pods, number of seeds per pod, pod size, weight of one hundred grains, chlorophyll a, b and total chlorophyll, carotenoid, relative water content, stomal conductance, sodium and potassium of seed and proline were studied. The variance analysis showed that the effect of irrigation on weight of one hundred grains weight were observed in 16 and 8 days irrigation cycles, respectively. The effect of foliar application of silicon, increased plant height and plant dry weight. Also the effect of foliar application of proline, increased seed potassium and decreased stomal conductance. The interaction of irrigation and silicon foliar, increased stomal conductance and plant dry weight but decreased proline. Also the interaction of irrigation and proline foliar, increased chlorophyll a, b, total, carotenoid and grain yield. The interaction of foliar application silicon and proline, increased chlorophyll a, b and total chlorophyll but decreased proline. Also interaction of irrigation cycle, foliar application of silicon and proline increased the number of pods per plant. Therefore, according to the result, can be said that foliar application of proline has a better effect on plants than silicon.