Abstarct: Concerning the cadmium toxicity at low concentrations and the behavioral similarity between zinc and cadmium ions, in order to investigate the effect of cadmium and zinc on plant growth and cadmium accumulation in spinach and radish, a factorial experiment baxsed on a completely randomized design with three replications was done in the greenhouse of Shahrood University of Technology in 2018. Cadmium and zinc, both from their sulfate sources, were applied in three concentrations (0, 10 and 20 mg/kg soil) as the experimental treatments. The results showed that in spinach, plant height, leaf area, fresh and dry weight and Cd concentration in areal part were significantly influenced by the different soil Cd concentrations. Moreover, in terms of radish, soil Cd concentration significantly affected the root length, leaf area, fresh and dry root weight and Cd concentration in root and areal part; whereas, shoot height and shoot fresh and dry weight of radish were not impacted by cadmium. The increasing effect of zinc on plant height, leaf area, fresh and dry weight of aerial parts of spinach were significant, but in radish, zinc application had no significant effect on the studied traits. In addition, the reciprocal effects of cadmium and zinc application on plant height, fresh and dry weight and shoot cadmium concentration in spinach was significant; whereas in radish, only root cadmium concentration was significantly influenced by these reciprocal effects. In both plants (spinach and radish), the highest Cd uptake was observed at the highest level of soil contamination with Cd (20 mg Cd/kg soil) and the lowest amount was in control treatment (without Cd), i.e., with the increase of soil cadmium level, the amount of cadmium absorbed in shoots of both plants increased significantly. In this case, higher zinc levels increased the uptake and concentration of cadmium in areal parts of both plants, but the effects of cadmium toxicity on growth characteristics were less observed. Increased soil Zn concentrations had no considerable influence on root Cd content in radish plant.