Abstarct: This research was carried out as split plot baxsed on randomized complete block design with 3 replications in a field in Damghan to evaluate the drought resistance of some sorghum varieties. Factors were 2 irrigation levels (the conventional irrigation intervals, i.e. 9-day, as control, and 18-day intervals as low-irrigation) in the main plots and 6 sorghum varieties (Speedfeed1, Sepideh, Kimia, Payame, Speedfeed2, and Pegah) in subplots. The analysis of variance results indicated that the effect of drought stress was significant on all traits. Except 1000-seed weight, the interactions of variety and stress were significant on all attributes. With respect to growth and grain yield, the Kimia varety was superior to others. The value of electrical conductivity was higher in low-irrigation than conventional irrigation conditions.The highest amount of electrical conductivity was measured for stressed-Sepideh variety. Drought stress caused a decrease in relative leaf water content of all varieties. Under low-irrigation conditions, the lowest leaf water content was devoted to Pegah and Speedfeed1 varieties. The highest activity of poly phenol oxidase enzyme activity was obtained for Sepideh variety under low-irrigation conditions. For Kimia and Sepideh varieties, the activity of guaiacol peroxidase was higher in stressed-plants than non-stressed-plants. For other varieties, this difference was not significant. It was obtained no significant relation between the activity of guaiacol peroxidase in stressed-plants and impressionability from drougt.