Abstarct: The potato tuber moth Phthorimaea operculella (Zeller) is one of the most important pests of potato, Solanum tuberosum L., in storage and farms. Due to harmful effects of pesticides and development of resisstance in potato tuber moth to some chemical insecticides, use of resistant cultivars and essential oils of medicinal plants have been considered to control this pest. This study was performed in order to investigate of the effects of antixenosis and antibiosis leaf and tuber of potato cultivars including Agria, Arinda, Baneba, Picasso and Sante for leaf and Agria, Arinda, Caesar, Ranumi and Sante for tuber and both of which were with four essential oils including Ferula asafoetida L., Lemron peel (Citrus lemon L.), Origanum suriacum L. and Satureja hortensis L. on oviposition deterrence and nutritional repellency. All experiments except the experi Olfactometer apparatus was performed at temperature of 25±1, relative humidity 65±3% and phoment using to period of 16 hours dark and 8 hours light. The effect of leaf and tuber cultivars on oviposition and penetration of potato tuber larvae was performed on completely randomized design with five treatments and three replications. The results of this experiment showed that the average oviposition of adult insect, have significantly different between different potato cultivars; so that the minimum number of eggs were laid on the leaf of Baneba cultivar, the tuber of Agria cultivar and the maximum number of eggs were on the leaf and tuber of Arinda cultivar. Also the feeding of first instar larvae of potato tuber moth had a significant difference between potato tuber cultivars. The highest and lowest rate of attraction was observed on the leaf and tuber of the Arinda cultivar and leaf of Baneba cultivar (9/96) and tuber of Agria cultivar (11/67) respectively. Effect of deterrence and repellant percentage of potato cultivar and essential oils of medicinal plants was examined in on completely randomized design with 5 x 4 factorial design including 5 potato cultivars and 4 essential oils of medicinal plants with 3 replications. The results of experiment showed that the all of essential oils had properties of oviposition deterrence. Essential oil of Origanum suriacum and essential oil of Citrus lemon had highest and lowest effect of deterrence, respectively. The mutual effect between leaf and tuber of potato with essential oil was significant for oviposition deterrence. The interaetion interaetion of leaf and essential oil was not significant on rate of repellency. While the interaetion effect of potato tuber with essential oil was significant (P= 0/0980). The highest rate of repellency was observed on the leaf of the Baneba cultivar with essential oil of Ferula asafetida and tuber of Agria cultivar with essential oil of Origanum suriacum. Antibiosis effect of potato cultivars without presence of essential oil was performed in completely randomized design with five treatments and three replications. The feeding of larvae on leaves and tubers had significant effect on penetration percentage, percentage of larval survival, pupal survival percentage, development period of immature stages and development period of adult insect. Antibiosis effect of potato cultivars and essential oils of medicinal plants was performed on completely randomized design with 5 x 5 factorial design including 5 potato cultivars and 4 essential oils of medicinal plants and distilled water as a control treatment with 3 replications. Feeding of larvae on leaves of different cultivars which covered with essential oils of medicinal plants had a significant effect on larval development period, pupal development period, larval penetration percentage, percentage of larval and pupal survival. However, there was no significant effect on the development period of immature stages and development period of adult insect. The feeding on five cultivars of potato covered with essential oils, showed a significant effect on the larval penetration percentage. The results of the above experiments showed that Agria cultivar in comparison to other cultivars is an undesirable cultivar for growth and development of potato tuber moth. Also the results of this study indicate the high fumigant toxicity of essential oil of Origanum suriacum on this pest. In the other words, can be used of Agria cultivar with essential oil of Origanum suriacum Can be used in the integrated pest management program of potato tuber moth.