Abstarct: The effect of two plant growth-promoting rhizobacteria (PGPR) strains, Streptomyces strain C-2012 and Streptomyces strain S2, on growing wheat cultivars in salt stress, has been studied under greenhouse conditions. The study included growth parameters, mineral concentration, antioxidant enzyme activity level and gene exxpression patterns sod,apx and gst in salinity condation. Salinity reduced plant growth, but PGPR inoculation reduced its harmful effect salinity. Plants inoculated with PGPR under saline conditions showed, increase dry weight steem and root and prolin content,chl a,b, carotenoid content as compared to non-inoculated. PGPR inoculated plants showed reduced concentrations of Na and Ca as compared to non-inoculated plants under saline conditions. Plants inoculated with PGPR under saline and non saline conditions also showed significant variations in antioxidant activity levels SOD, APX, GST, CAT and POX. In response to salt stress and inoculated PGPR results showed that gene exxpression patterns ascorbate peroxidase (APX) and glutathione-stransferases (GST), Superoxide dismutase (SOD) were significantly different in these two cultivars. The results obtained from this study suggest that S.strain C-2012 and S.Strain S2 can be used to alleviate salt stress in wheat plants. Also, no correlation was observed between mRNA and enzyme activity in some cases, which indicate that post-transcxriptional and post-translational regulations may play major roles.