Abstarct: In order to study the effect of nitrogen fertilization (from urea 46% source) and foliar boron element (boric acid source) on quantitative and qualitative characteristics of bitter melon plant. an factorial experiment was conducted in a randomized complete block design with 3 replications was performed in the agriculture college of University of shahrood at the summer of 1392 year. The studied treatments consisted of three levels of N: 75, 150 and 225 kg per hectare for the first factor and four levels of B (0, 1, 2 and 3 per thousand) was considered as the second factor. Results showed improved vegetative and reproductive growth of plants treated with 150 kg/h Nitrogen than 75 kg were treated. 150 kg per/h treatment led to a significantly increase in flowering, seed number, shoot growth, dry matter and yield, leaf chlorophyll, nitrate reductase enzyme and Nitrogen, Potassium and Phosphorus nutrients in the karela plant. But with the increase in the amount of Nitrogen to 225 kg In most of the characteristics studied, there was no significant difference compared to 150 kg and or even was negative effects. The results showed that spraying boric acid also had a significant effect on most of the characteristics studied and in particular the two per thousand treatment improved plants vegetative and reproductive characteristics in compared to other treatments. But with the increase in the amount of Spraying to three per thousand led negative effects that probably due to the effect of Boron toxicity. It was found that the interaction between Nitrogen latter level and Boron third level (two per thousand) has the greatest effect on seed thousand weight, length of branches, yield, leaf nitrate and fruit Phosphorus.