Abstarct: The use of treated domestic sewage for irrigation is becoming a common practice, because of the shortage of freshwater resources. Irrigation with wastewater plant effluent can be either beneficial or harmful. In order to study the effect of irrigation with treated wastewater on some soil properties, an experiment was conducted at north Isfahan province in 2009. In this study five agricultural fields which have been irrigation with treated wastewater were compared to four fields irrigated with wells water. Composite soil samples were taken from the fields from 0 to 60 cm of soil depth with 30 cm intervals (62 composite soil samples). All soil samples were prepared and analyzed for some properties using standard frequently used methods. Also the plant samples were collected and analyzed for transport some nutrients and heavy mextals to wheat, corn, alfalfa and cantaloupe (52 plants samples). The results showed that the amount of bulk density (Db) in soils were lower in wastewater irrigated soils compared to other fields in both depths. Electrical conductivity (EC) and sodium absorption ratio (SAR) in soil were significantly lower in wastewater irrigated soils than well water irrigated. Hydraulic conductivity (Ks) and water hold capacity in soils irrigated with wastewater was higher than wells, but was not significant. The amount of nitrogen (N) in soils were higher in wastewater irrigated soils compared to other fields. Phosphorous (P) concentrations in soil were significantly higher in wastewater irrigated fields than well water irrigated. Potassium (K) concentrations in soil irrigated with both source of irrigations were almost similar. In the depth of 30-60 cm, nutrients showed lower concentrations than 0-30 cm in soils. The amount of cadmium (Cd), manganese (Mn) and iron (Fe) in soils were higher in wastewater irrigated soils compared to other fields. Zinc (Zn), lead (Pb) and cupper (Cu) concentrations in soil irrigated with both source of irrigations were almost similar. However, in the depth of 30-60 cm, many mextals have showed lower concentrations than 0-30 cm in soils indicating greater mextals accumulations in the surface soil laxyer. Irrigation of wheat and alfalfa with wastewater had not significant effect on the accumulation of elements. Irrigation with wastewater caused significant increase N and P in shrub of corn and nitrogen (N) in cantaloupes fruits. Irrigation of wheat and alfalfa with wastewater had not significant effect on the accumulation of elements. Irrigation of corn with wastewater caused significant increase Mn in grain, but these concentrations were lower than recommended maximum concentration. Using treated wastewater to irrigate cantaloupes increased cadmium (Cd) accumulation in cantaloupes fruits to the range of 0.4 to 1 mg/kg dry weight indicating possible potential risk while the corresponding data for wells water was found no any detectable cadmium (Cd) in the fruits. In general, the results showed that the heavy mextals concentration in crop has not significant different in irrigation with wastewater and wells water, there appears to be no significant risk associated with the irrigation of these crops with treated wastewater.