Abstarct: The Irankuh is one of the largest Zn-Pb deposits in Iran. This study aimed at evaluating the concentration and partitioning of potentially toxic elements in mine tailings and soils around the mine, in order to assess the mining impacts on soil pollution. For this purpose, 28 surface soils and 2 tailing samples were taken and analyzed for physico-chemical properties (pH, OM, CEC, Carbonate, and texture), total content and elemental speciation using standard methods. The obtained data were analyzed using statistical approaches (correlation coefficients, cluster analysis, PCA, and ANOVA) and geochemical indices (EF, Igeo, MF, ICF, GCF). Results showed that the surface soils are polluted by As, Ba, Cd, Pb, Sb and Zn. All elements (except Cu) have higher concentration in mine soils compared with agricultural ones. The soils are not polluted with Al, Ti, Zr, Sc, Fe, Mn, Cu, Cr, Co, and Ni. The tailing samples are more polluted than soils, and the concentration of studied elements (except Cr, Ni, Co, Al, Zr, Sc, Ti) in tailing samples were high. Tailings are much more polluted with As, Cd, Sb, Zn and Pb. Speciation study indicated that in the mine soils and distant agricultural soil, As, Cd, Pb and Fe are not present as exchangeable phase, whereas agricultural soils affected by tailings have high exchangeable phase of these elements. On the other hand, in distant agricultural soil, Cr, Cu, Zn and Ni present as exchangeable, and organic bound fraction of these elements were high in this sample. Thus, agricultural activity participates in soil pollution with Cr, Cu, Zn and Ni. In the studied soils, Fe and Cr are mainly associated with residual phase, thus they are derived form natural sources. Other elements (especially Mn, Cd, Pb and Zn) are mainly present in non-residual fractions, thus they are from anthropogenic sources and have high mobility and bioavailability.