Abstarct: Gorganroud is an important river in Golestan province, which plays an important role in province water supply. This study aimed to assess the quality of Gorganroud water and sediment at Gonbad-e-Kavoos district. For this purpose, 30 water, 6 wastewater and 10 sediment sample and were colleted. the concentration of major ions, phosphate and nitrate of in water samples as well as the concentration of potentially toxic elements in sediment samples were measured using standard methods. The hydrochemical investigations show that the prevailing water types of Gorganroud and its turbituries are Na-SO42- and Na-HCO3-, respectively. The concentrations of major ions in upstream were high, but the entrance of turbitouries enhances the Gorganroud water quality for drinking and agricultural uses. Along the river path, the processes of mineral dissolution (gypsum, halite and anhydrite) and ion exchange occur, which deteriorate the water quality. Urban sewages and effluents have better quality than river water samples, thus, the major reasons for the low water quality of Gorganroud are natural processes (i.e. evaporation, mineral dissolution, etc.). The concentration of potentially toxic elements in sediment samples were evaluated using geochemical indices (EF, CF, PLI) and statistical analysis. The results confirm the effect of anthropogenic sources (i.e. agricultural runoff and urban sewage) on the elemental content of sediments, especially within the Gonbad City district. The concentration of Pb, Cr, Cr, Zn, and As was high Compared to in mean Concentration of world sediments. The results of three-step sequential extraction of As confirms the effects of anthropogenic activities on sediment contamination.