Abstarct: Arid and semi-arid areas such as Iran, are facing water crisis and long-term droughts in recent years. One option to cope with this situation is the use of treated or untreated wastewater for irrigation of the cultivated lands. Depending on the nature of its composition, irrigation water supply can have beneficial effects or harmful on soils. To evaluate the effects of wastewater irrigation on soil quality, the present research was conducted in the south of Tehran (Rey area) are irrigated with raw wastewater since 1352. For this purpose 44 soil samples were collected from depths of 30-15 cm and 15-0 cm within three zones irrigated by wastewater (zone F), irrigated with effluent (zone E) and irrigated with groundwater (zone S). Some features of physical-chemical (organic matter and texture) and concentrations of some nutrients and heavy mextals (Cr, As, Cu, Pb, P, Cd and Zn) were measured in the soil samples. The obtained results show that the soil organic matter increased dramatically from 0.2 to 2.47% and concentrations of some heavy mextals (Zn 3.12 mg/kg, Pb 72 mg/kg and Ni 48.5 mg/kg on average) are substantially elevated in soils. the results also indicated that in three types of water used in three zones, concentrations of some mextals in the wastewater is high as compared with permissible limits thereby they can accumulate in the soils irrigated with wastewater. Finally statistical analysis indicated that two main factors i.e. application of chemical fertilizers and use of wastewater are the most important origin of mextal contamination in the soil of the study area.