Abstarct: In this work, synthesis of new derivatives of imidazo[2,1-b][1,3] thiazole through palladium-catalyzed heteroannulation is reported. Treatment of 4,5-diphenyl imidazole-2-thione(208) with propargyl bromide(199) in refluxing ethanole affords 4,5-diphenyl-2-propargyl mercaptoimidazole (209) in good yields. When compound(209) in DMF was reacted with aryl iodides and triethylamine in the presence of bis(triphenylphosphine) palladium chloride(II) and cuprous iodide at 70C, new derivatives of 3-aryl imidazo[2,1-b][1,3] thiazole(210a-e) were obtained. The reactions were carried out under an argon atmosphere, and the DMF and triethylamine mixture was degassed prior to use.