Abstarct: In this study a simple and sensitive induction period baxsed kinetic spectrophotometric method was reported for determination of trace amounts of piroxicam. The method is baxsed upon inhibition effect of piroxicam on the catalytic oxidation of mete creosol purple(MCP) with periodate. In the presence of piroxicam an induction period was appeared in the reaction system, which is proportional to the piroxicam concentration. The decolorization of Mcp at 525nm was used to monitor the reaction spectrophotometrically. Under the optimum conditions piroxicam can be determined in the range of 1-12.5 microM (0.33-4.14 micro-g/ml) with a 3σ detection limit of 0.54microM (0.18 micro-g/ml). The relative standard deviations for six replicate determinations of 1.25, 5.0 and 10.0microM piroxicam were 1.02%, 0.27% and 0.22%, respectively. This method was successfully used in the determination of piroxicam in various pharmaceutical products.