QD325 : Synthesis of 1,2,3-triazoles lixnked quinazoline system by copper catalyzed click reation
Thesis > Central Library of Shahrood University > Chemistry > MSc > 2018
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Abstarct: Reaction of ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylate and related amide compounds with propargyl bromide afforded ethyl 4-oxo-3-(prop-2-yn-1-yl)-3,4-dihydroquinazoline-2-carboxylate and amide propargylated compounds. Treatment of prepared compounds with aromatic azides or sodium azide and benzyl chloride in the presence of copper(II) acetat, 4-amino-5hydroxy naphthalene-2,7-disulfonic acid mono sodium salt as a ligand and sodium ascorbate in water afforded new derivatives of 1,2,3-triazole-lixnked quinazoline-4-one scaffold with good-to-high yields.
Keywords:
#Quinazoline #1 #2 #3-Triazole #Copper(II) acetate #Sodium azide #benzyl chloride Link
Keeping place: Central Library of Shahrood University
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Keeping place: Central Library of Shahrood University
Visitor: