Abstarct: Pyrano[2,3-d]pyrimidines have several biological properties. So, providing a new methodology and synthesis of new derivatives are of interest. In these research catalyst-free three-component reaction of aldehydes, malononitrile and 1,3-dimethylbarbituric acid in reflaxing, magnetized water afforded to 7-amino-1,3-dimethyl-2,4-dioxo-5-phenyl-1H-pyrano[2,3-d]pyrimidine-6-carbonitrile in good-to-high yields. Catalyst-free, short reaction time, green solvent and good-to-high yields were some advantages of this method.