QD304 : Multi-componet synthesis of 1,2,3-triazoles from carboxylic acids, propargyl bromide and azides
Thesis > Central Library of Shahrood University > Chemistry > MSc > 2017
Authors:
Abstarct: 1,2,3-Triazole compounds have an important role in organic synthesis, medicinal chemistry, drug discovery, agrochemicals, as well as dyes and having diversity biological activities. In this work new drivatives of (1-aryl-1H-1,2,3-triazol-4-yl)methyl alkanoate were prepared through the three-component reaction of carboxylic acids, propargyl bromide and aromatic azides in the presence of copper(II) sulfate and sodium ascorbate in DMF. These one-pot processes provided an efficient and direct method for the synthesis of ester functionalized 1,2,3-triazoles with high yields. All of the synthesized compounds were characterized by 1H-NMR, 13C-NMR and FT-IR analysis.
Keywords:
#1 #2 #3-Triazole #Copper(II) sulfate #Sodium ascorbate #Carboxylic acid #Click reaction Link
Keeping place: Central Library of Shahrood University
Visitor:
Keeping place: Central Library of Shahrood University
Visitor: