QD293 : Synthesis of new 1, 2, 3-triazoles with amide substitution via click reaction
Thesis > Central Library of Shahrood University > Chemistry > MSc > 2017
Authors:
Mansooreh Abdollahzadeh [Author], Ali Keivanloo[Supervisor], Hossein Nasr Isfahani[Advisor]
Abstarct: 1,2,3-Triazoles are important nitrogen heterocyclic compound and have been found to possess a board spectrum of biological activites. In this work new 1,2,3-triazoles were prepared through multi-component reaction of primery and secondary amines, 2-chloroacetyl chloride, sodium azide and terminal alkynes via copper-catalyzed click reaction. Reaction of 2-chloroacetyl chloride with amines, afforded 2-chloroacetamide followed by azide substitution and copper-catalyzed click reaction with terminal alkynes Led to 1,4-disubstitude 1,2,3-triazoles in high yields. All of the synthesized compounds were characterized by FT-IR, 1H-NMR and 13C-NMR.
Keywords:
#1 #2 #3-Triazoles #2-Chloroacetyl chloride #Cupper (II) Acetate Link
Keeping place: Central Library of Shahrood University
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