QD244 : Three-component synthesis of 1,2,3-triazoles by 1,3-dipolar cycloaddition reaction in the presence of PVC-supported ethylendiamine-copper catalyst
Thesis > Central Library of Shahrood University > Chemistry > MSc > 2015
Authors:
Abstarct: 1,2,3-triazoles have several biological properties. So, providing a new methodology and synthesis of new derivatives are of interest. In this project, firstly Cu+2-Ethylenediamine complex as a novel heterogeneous catalyst was immobilized on PVC, then its application in synthesis of 1,2,3-triazole was studied.
Multiple component reactions of propargyl bromide, amine and aromatic azide in the presence of PVC-EDA-Cu+2 as a catalyst and sodium ascorbate as a reducing agent in water at ambient temperature was produced 4-((1-(aryl)-H-1,2,3-triazole-4-yle)methyl)amine in 82-94% yeilds. Moreover, compound of 4-((1-(aryl)-H-1,2,3-triazole-4-yle)methoxy)benzaldehyde was produced with high yields from the reaction of propargyl ether with aromatic azide in the presence of PVC-EDA-Cu+2 in magnetiged water.
The advantages of this method consist of using water as a green solvent, high yields, short reaction time and recycablity of the catalyst.
Keywords:
#PVC #Three-component #1 #2 #3-Triazole #Sodium Ascorbate #Propargyl bromide Link
Keeping place: Central Library of Shahrood University
Visitor:
Keeping place: Central Library of Shahrood University
Visitor: