QD243 : Synthesis of new 1,2,3-triazoles from acetylenic triazine and benzotriazine compounds
Thesis > Central Library of Shahrood University > Chemistry > MSc > 2015
Authors:
Abstarct: Reaction of 6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one and 1,2-dihydro benzo[e][1,2,4]triazine-3(4H)-thione with propargyl bromide, afforded 6-methyl-3-(prop-2-ynylthio)-1,2,4-triazin-5(4H)-one and 3-(prop-2-ynylthio)-1,4-dihydrobenzo[e] [1,2,4]triazine respectively. Treatment of these prepared compounds with aromatic azides in the presence of copper(ІІ)acetate and sodium ascorbate in DMF or EtOH produced new derivative of 1,2,3-triazole-lixnked 1,2,4-triazine and 1,2,4-benzotriazine with good-to-high yields.
In continue novel 1,2,3-triazole beased on the mention heterocyclic scaffolds were prepared using aliphatic halides, sodium azide and realated acetylenic compounds via copper-catalyzed click reaction.
Keywords:
#1 #2 #3-triazole #copper (ΙΙ) acetate #sodium azide #1 #2 #4-triazine #aliphatic halide Link
Keeping place: Central Library of Shahrood University
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Keeping place: Central Library of Shahrood University
Visitor: