Abstarct: In This work efficient synthesis of derivatives of [2,3-b]pyrrolopyrazine through Palladium-Catalyzed heteroannulation has been reported. When compounds 5,6 dichloropyrazine-2,3-dicarbonitrile, hydrazine and various aromatic aldehydes was treated with phenylacetylene in DMF in presence of PdCl2(PPh3)2, cuprous iodide at 80℃ , under argon atmosphere, new derivatives of 2-phenyl-N-arylmethylene-1-H-pyrrolo[2,3-b]pyrazine were obtained in good to high yields. The structure of products were stablished by spectroscopic data obtained. In conclusion the described method for the synthesis of N-substituted pyrrolopyrazine is an easy one-pot procedure which gave rise to good to high yields of the desired products.