QD225 : synthesis of biologically active new 1,2,3- triazoles
Thesis > Central Library of Shahrood University > Chemistry > MSc > 2014
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Abstarct: Triazoles are important class of compounds in drug discovery and material science. In this work new derivatives of 1,2,3-triazoles lixnked to quinoxaline ring were prepared by click reaction. At first step acetylenic componds of the 2-chloro-3-(prop-2-ynyloxy)quinoxaline and 2,3-bis(prop-2-ynyloxy)quinoxaline were prepared by reaction of 2,3-dichloroquinoxaline with propargyl alcohol in DMF. In continue, the reaction of these acetylenic heterocyclic compounds with aromatic azides in the presence of CuSO4 and sodium ascorbate, lead to the formation of desired 1,2,3-triazole compounds in high yields.
Keywords:
#1 #2 #3-Triazole #Copper(II)sulfate #Click chemistry #Quinoxaline Link
Keeping place: Central Library of Shahrood University
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Keeping place: Central Library of Shahrood University
Visitor: