QD206 : The synthesis of 1,2,3-triazole derivatives
Thesis > Central Library of Shahrood University > Chemistry > MSc > 2014
Authors:
Sajad Hashemizadeh [Author], Mohammad Bakherad[Supervisor], Hossein Nasr Isfahani[Advisor]
Abstarct: 1,2,3-Triazoles have attracted interest over the past few years as their moieties have been widely used in pharmaceuticals, agrochemicals, dyes, photographic materials, corrosion inhibition. In this research we have developed eggshell-CuI as a green catalyst for the synthesis of 1,2,3-triazoles. This one pot preparation of 1,2,3-triazoles involves initial substitution of alkyl halides with sodium azide to generate in situ alkyl azides which is followed by copper catalyzed cycloaddition reaction with alkynes in water at room temperature. The present method described here is simple, facile and can be applicable to a wide range of substrates with high functional group tolerance.
Keywords:
#1 #2 #3-triazole #Eggshell copper (I) catalyst #Sodium azide Link
Keeping place: Central Library of Shahrood University
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