QD144 : Three component reaction of Imidazo[1,2-c]pyrimidine
Thesis > Central Library of Shahrood University > Chemistry > MSc > 2012
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Abstarct: 3-(cyclohexylamino)-7-hydroxy-2-phenylimidazo[1,2-c]pyrimidin-5(6H)-one derivatives were synthesized in moderate to high yields in one-pot three component reaction from the corresponding aldehydes, cyclohexyl isocyanide compounds and 4-amino uracil, in the presence of catalytic solid acid as a non-toxic, inexpensive and easily available reagent, under solvent-free conditions at 50˚C. Compared to the classical Passerini reaction, this new method consistently has the advantage of good yields.
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