Abstarct: In this research, a method for synthesis a palladium (II) complex baxsed on Carbon Nano Tube (MWCNT) and optimization of the Sonogashira coupling reaction by this nanocatalyst, were devised. The carboxylated Acid carbon nano tube (MWCNT-COOH), has been reacted with thionyl chloride under Argon atmosphere to give the Chlorided compound. Then, the compound MWCNT-COCl was heated in presence of baxse and Cysteamine in the DMF as solvent. By this process, the MWCNT-CO-Cysteamine has been synthesized. MWCNT-CO-Cysteamine and palladium (II) benzonitrile chloride complex were stirred in the DMF as solvent until the MWCNT-Cysteamine-Pd, produced. In order to optimization of conditions of the Sonogashira coupling reaction, first the effect of baxse on the reaction yield, were experimented. Then, the most suitable baxse was used to the reaction between some aryl halides and acetylene derivatives by the nanocatalsyt.