QD127 : Synthesis of alkynes drugs catalyzed by PVC-Pd(II) complex
Thesis > Central Library of Shahrood University > Chemistry > MSc > 2012
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Abstarct: We have developed a clean protocol for copper-free Sonogashira reactions catalyzed by PVC-anchored Pd(II) phenyldithiocarbazate complex under aerobic conditions.
PVC was treated with phenylhydrazine and carbondisulfide in the presence of KOH in EtOH at 80 ºC to produce the corresponding PVC-anchored phenyldithiocarbazate ligand.This was then reacted with [PdCl2(PhCN)2] in EtOH at 80 ºC to yield the PVC-anchored Pd(II) phenyldithiocarbazate complex Catalyst was characterized by FT-IR, SEM, and ICP.
The catalytic activity of PVC-anchored Pd(II) phenyldithiocarbazate complex (1 mol %) was studied at room temperature under aerobic conditions in a copper-free Sonogashira reaction using terminal alkynes and aryl halides. The supported catalyst could be reused for several times without a significant degradation in its catalytic activity.
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