QC647 : Investigating the effect of the concentration of silver nanoparticles (Ag) in MAGIC-F polymer gel on the absorbed dose of gamma rays from 241Am and 137Cs Source.
Thesis > Central Library of Shahrood University > Physics > MSc > 2025
Authors:
Abstarct: Radiotherapy is considered one of the most effective methods in cancer treatment; however, achieving an adequate therapeutic dose in the tumor tissue while minimizing damage to the surrounding healthy tissues remains a major challenge. Despite significant advancements in technology and treatment delivery systems, there is still a demand for higher precision in improving radiation absorption efficiency within the target tissue. One of the novel approaches to enhance radiotherapy performance is the use of high-atomic-number mextallic nanoparticles as radiosensitizers, since these nanoparticles can increase the probability of the photoelectric effect, thereby enhancing radiation energy absorption in the tumor region.
In this context, the present study investigates the effect of silver nanoparticles (AgNPs) on the dosimetric properties of MAGIC-F polymer gel. Owing to its tissue equivalence, high radiation sensitivity, and capability of three-dimensional dose recording, this gel represents one of the effective options for accurate dosimetry in radiotherapy. In this work, samples of MAGIC-F gel with various concentrations of silver nanoparticles were prepared. The gels were fabricated with high precision baxsed on a composition of gelatin, methacrylic acid, ascorbic acid, copper sulfate, and formaldehyde. The silver nanoparticles were ultrasonically dispersed into the gel solution to achieve homogeneous distribution, followed by a controlled cooling process to prevent sedimentation.
The prepared samples were irradiated with gamma photons from ^241Am and ^137Cs sources. Parameters such as absorbed dose, transmission factor, and linear and mass attenuation coefficients were extracted from the experimental data and compared with theoretical values obtained using the XCOM software.
The results revealed that increasing the concentration of silver nanoparticles led to an enhancement in radiation absorption and a reduction in transmission. This effect was more pronounced at lower photon energies, such as those from the ^241Am source, which is consistent with the dominance of the photoelectric effect in this energy range. At higher energies, an increasing trend in absorption was also observed, although the magnitude of the changes was smaller.
Overall, the findings of this study demonstrate that incorporating mextallic nanoparticles into polymer gels can significantly improve the performance of three-dimensional dosimeters and enhance the accuracy of absorbed dose measurements. Therefore, silver-nanoparticle-enhanced MAGIC-F polymer gel can be proposed as a novel approach for improving dosimetry performance and increasing radiotherapy efficiency in target tissues.
Keywords:
#MAGIC-F polymer gel #silver nanoparticles (AgNPs) #gamma radiation #241Am and 137Cs sources #three-dimensional dosimetry #transmission factor #mass attenuation coefficient #radiotherapy #XCOM databaxse Keeping place: Central Library of Shahrood University
Visitor:
Visitor: