QC451 : Stady of magnetic drug dlivery on Therapeutic dose in BNCT
Thesis > Central Library of Shahrood University > Physics > MSc > 2018
Authors:
Jafar Alaeddin [Author], Sohani Moslem[Supervisor]
Abstarct: The BNCT (Borne Neutron Capture Therapy) is a purposive and developing radiation therapy that, by selective property, causes the least damage to the healthy tissue and in some cases is the only effective therapeutic approach. Over the past 80 years, researchers have been struggling to eliminate the challenges of this treatment. In this regard, the sources of neutron production and the creation of a suitable neutron beam to reduce damage to healthy tissue have been much studied. In recent decades, researchers have studied new compounds and new methods, including magnetic drug guidance for this purpose. Drug tracking is one of the processes that can help cure many diseases. But with a better control of the drug's pathway, the tumor in the body can be destroyed with the least damage to healthy tissues of the body. In a magnetic drug delivery, tumor-destroying drug agents or cancer cells are loaded onto a magnetic molecule that prevents the accumulation of these drugs in other parts of the body and healthy tissues by applying an external magnetic field. It will be. In this way, the unwanted side effects of conventional chemotherapy are dramatically reduced. This led us to design a magnetic field using the CST software to direct and concentrate in the tumor area to the desired depth of the magnetic molecules of the boron drug. By concentrating and increasing the concentration of the drug in the tumor area, the area of the reaction in the tumor area is narrowed. This leads to an increase in the absorbed dose in the tumor region, which reduces damage to the healthy tissue around it. In this thesis, while studying the magnetic field from a Helmholtz Swing and the effect of possible geometric arrangements on the resulting field, the accumulation of doses due to the accumulation of boron by the simulation of MCNP has been shown.Exercising this idea will reduce the challenges of the BNCT treatment and lead to improved treatment performance.
Keywords:
#BNCT #magnetic field #targeted drug delivery #Helmholtz Swarm #CST #Earnshaw’s theorem & McNP. Link
Keeping place: Central Library of Shahrood University
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