QC200 : Calculating absorbed dose in 153Sm permanent prostate brachytherapy seed implants benefiting from Monte Carlo approach
Thesis > Central Library of Shahrood University > Physics > MSc > 2013
Authors:
Abstarct: Brachytherapy or Internal Radiation therapy is one of the most effective treatments of
prostate cancer. On this procedure, the brachytherapy radionuclide seeds are implanted
into the target tissue directly or they are placed a few millimeters far from it. For
prostate brachytherapy, Gamma emmiter sources such as iodin-125, Palladium-103 and
Beta emmiter sources such as samarium-153 are applicable. At this research, permanent
brachytherapy prostate is simulated for samarium-153 seed, and then absorbed dose is
evaluated using Monte Carlo simulation. Since adult male phantom is not consisted of
prostate tissue, prostate gland is attached to phantom as sphere with 2.2 cm radius.
Deponding on volume of prostate gland, between 50 to 120 seeds are implanted into
prostate gland. 83 samarium-153 seeds are placed at various locations in the prostate
gland. Samarium-153 emitts gamma and beta particles, therefore, delivery dose to
organs of body is calculated separately for beta and gamma particles then the total dose
is obtained by adding these two doses. For beta particles, simulation is performed with
coupled electron-photon transport to take bremsstrahlung into account. The continuous
beta spectrum of Samarium-153 is obtained and values of density probability are used in
simulation of source. The tally *F8 is applied to calculate the deposited energy (in terms
of MeV). The absorbed dose per transformation in can be calculated by
means of mass of organs and initial activity of seeds. Delivery dose to prostate gland
cause by implanting samarium-153 seeds are compared to cylindrical iodin-125 seeds
and point sorce of iodin-125. Dose delivered to prostate gland and neighboring tissues
due to implant of samrium-153 seeda are compared with obtained results of iodin-125 in
other works. Delivery absorbed dose to prostate gland cause by implanting 100, 88 and
80 I-125 seeds are 147.2, 149.4 and 137.59 Gy while at this research the value of
obtained dose due to implant of Sm-153 seeds is 160 Gy. At this work dosimetry
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parameters TG-60 are calculated for Sm-153 using Monte Carlo methods. The tally *F8
is applied to evaluated energy deposited in water phantom. At the Monte Carlo code,
the density of materials considered zero to find geometry function. According to the
values of deposited energy and geometry function, the anisotropy function and the
radial dose function are calculated. The values of anisotropy function and radial dose
function are compared to consequences of other works, which not considering beta
spectrum in simulation. By comparing results, the differences are observed even up to 5
times for anisotropy function at 0.6, 1 and 2 mm distances and some angles. For better
comparison, the simulation is performed for three energy lines without considering the
final beta spectrum. The maximum differences are observed for 3 mm distance and
angles of 0-60 degrees which are 14% to 47%. But the minimal differences are
determined for 0.6, 1 and 2 mm distances which are 1% to 8.4%. According to results,
the parameters dosimetry will change when the continuous beta spectrum of samarium
153 is assumed in Monte Carlo code.
Keywords:
#Brachytherapy #Dosimetry parameters #Samarium radioactive seed #Monte Carlo #Beta spectrum of samarium-153
Keeping place: Central Library of Shahrood University
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Keeping place: Central Library of Shahrood University
Visitor: