Abstarct: Introduction: The incidence of leg cramps is associated with high levels of blood glucose, triglycerides, blood pressure, obesity and decreased HDL in middle-aged women, the aim of this study was to investigate the effect of calf muscles and hamstrings stretching on the leg cramps in women with the mextabolic syndrome. Materials and Methods: The population of the study were all of the women with mextabolic syndrome in Fooman. 24 sedentary volunteer women, aged 50 to 60 years, were selected by purposive sampling. First, the leg cramps and mextabolic syndrome variables were measured, then subjects were randomly divided into two groups (experimental, n=12 and control, n=12). Stretching training was performed 6 weeks ((first 2 weeks was 3 times a week, second 2week was 4 times a week and last 2 weeks was 5 times a week, 45 to 50 minutes) for experimental group. The intensity and frequency of leg cramps were assessed by visual analogue scale. Results: Stretching training significantly reduced the intensity and frequency of leg cramps (p<0.05); while the severity of pain was not significant between the two groups. The mextabolic syndrome indices and anthropometric measurements before and after training was not significant the experimental group. Conclusion: In fact, this study expresses the interaction between stretching training and relaxation of leg muscles and reducing the frequency and severity of leg cramps in women with mextabolic syndrome. According to disorders that long-term cramps Complications make on the middle -age women quality of life and Considering unsuitable medical supplement and also side effects of quinine in patients, so performing simple and low risk stretching training reduce patients Immediate pain, and also can make Perfect background for improving the quality of life and sleep by increasing skeletal muscles elasticity and range of motion make in adults.