Abstarct: Introduction: Among sedentary subjects with high BMI and WHR, there is many cardiomextabolic risk factors. Regular exercise has protective effect on cardiovascular and all-cause mortality. Exercise makes white adipose tissue to brown adipose tissue. Irisin as a new Myokine seems to have a role in making white adipose tissue to brown. So we are investigating the effect of eight weeks resistance exercise on serum Irisin level and it’s relation to cardiovascular risk factors in prediabetic women. Materials and methods: Sedentary subjects with a high BIM and WHR voluntary participated in this study. Subjects divided randomly into two control (9) and experiment (11) group. They take part in eight weeks resistance exercise with 60% to 80% of 1RM. Blood samples were taken before and after exercise and analyzed in the laboratory. Cardiomextabolic risk factors include fasting blood sugar (FBS), triglyceride (TG), high lipoprotein density (HDL), systolic blood pressure (SBP), diastolic blood pressure (DBP) weight, body mass index (BMI), waist-hip ratio (WHR), body fat mass (BFM) and soft lean mass (SLM). Statistical analysis of the data was done by IBM SPSS Statistic 22 software. The data statistically analyzed using paired sample T test. Results: Irisin and cardiomextabolic risk factors (0/05>p) reduced significantly in respect to eight weeks resistance exercise in prediabetic women. But there were no significant relationship between Irisin and cardiomextabolic risk factors. SBP did not change significantly. Conclusion: We conclude eight weeks resistance exercise has an effective result on reducing cardiomextabolic risk factors but not in reducing systolic blood pressure. Irisin was reduced in respect to resistance exercise, too. There were no relation between Irisin and cardiomextabolic risk factors in this study.