Abstarct: Background and objectives: Kidney disease is one of the most common mextabolic diseases. Exercise is recommended to control the progression of this disease. Modifying underlying factors including regular physical activity is known as one of the most important interventions. Research shows that Physical activity can reduce the harmful factors of kidney disease. One of the most common risks of this disease is related to cardiovascular problems and arterial stiffness, which can be helped to improve by performing Physical activity. Materials and methods: The current research was conducted as a randomized clinical trial with 24 subjects suffering from kidney disease in stages 3 to 5, who were randomly assigned to 2 groups of aerobic exercise and control. The subjects did aerobic exercise on a treadmill for 12 weeks and three sessions in the sports club. Before starting the protocol and 48 hours after the last training session, measurements including body composition, arterial stiffness and blood sampling were performed to measure biochemical indicators. Findings: Data analysis showed that aerobic exercise increased the indicators related to kidney disease, including blood pressure, arterial stiffness, fetoin A and body fat percentage, and had significant effects (p < 0.05). Conclusion: It seems that in people with kidney disease, aerobic exercise has positive changes on mextabolic indicators. As a result, doing aerobic exercise can help treat these people along with drug treatment.