Abstarct: The aim of this study was to compare the effects of combined exercise training accompanied by saffron supplementation on depression, sleep quality, and thyroid hormone levels in young depressed women. The variables examined in this research included the combined exercise protocol and saffron supplementation as the independent variables, and depression, sleep quality, and thyroid hormone indices (TSH, T3, and T4) as the dependent variables. This semi-experimental study was conducted using a pretest–posttest design with a control group that was randomly assigned. In terms of data collection, the study was both field-baxsed and laboratory-baxsed, and in accordance with its objectives, it was classified as applied research. The sample consisted of 45 depressed women aged 18 to 35 residing in Shahroud who were selected purposefully baxsed on inclusion and exclusion criteria, and then randomly allocated into three groups: combined exercise with saffron supplementation, combined exercise with placebo, and control. For obtaining informed consent, all participants attended an introductory session one week prior to the experiment. baxseline measurements, including body configuration indices, the Hamilton Depression Rating Scale, the Pittsburgh Sleep Quality Index, and thyroid tests (TSH, T3, and T4), were performed on pretest days using methods and instruments described in Chapter Three. Subsequently, the intervention groups underwent an 8-week training protocol (three sessions per week); during this period, the intervention group received 30 mg of Doralife saffron capsules daily, while the combined exercise with placebo group received capsules containing an inert substance. After the intervention period, the body configuration indices, questionnaires, and thyroid tests were repeated, and the collected data were analyzed using the Shapiro–Wilk test, analysis of covariance (ANCOVA), and Bonferroni follow-up tests in SPSS version 26. The findings of the study indicated that both interventions—combined exercise training with saffron supplementation and combined exercise training with placebo—had significant effects in reducing depression, improving sleep quality, and moderating thyroid hormone indices compared to the control group. The Bonferroni follow-up tests also revealed that there was no significant difference between the combined exercise plus placebo and the combined exercise plus saffron groups in terms of reducing depression and improving sleep quality; for example, the mean difference in depression reduction was reported as -8.408 in the combined exercise plus placebo group and -7.923 in the combined exercise plus saffron group. Additionally, regarding thyroid variables such as TSH, T3, and T4, both interventions showed significant changes compared to the control group, while no significant difference was observed between the two intervention groups. These results demonstrate that combined exercise interventions, whether accompanied by saffron supplementation or placebo, have a positive effect on reducing depression, improving sleep quality, and moderating hormonal indices in young depressed women, with similar efficacy observed for both types of intervention. Consequently, it is recommended that such combined interventions be incorporated into treatment and rehabilitation programs for individuals suffering from depression and sleep disorders.