Abstarct: Diabetes is one of the most important health problems in all societies. Sports interference and drug interference, especially supplements, are among the best approaches to improve the condition of diabetics. The aim of the present study was the effect of synbiotics and aerobic exercise on serum adropin levels in postmenopausal women with type 2 diabetes. In this semi-experimental study, 39 qualified people were selected to enter the study and baxsed on fasting blood sugar, they were randomly divided into three groups: aerobic exercise + placebo (13 people), aerobic exercise + synbiotic supplement (13 people) and synbiotic supplement. Biotic (13 people) were divided. The program of aerobic exercises included 10 minutes of warm-up, 25 minutes of activity with an intensity of 40-45% of the maximum heart rate, which was added every two weeks by 5 minutes to the duration and 5% to the intensity of the activity, and 5 minutes of cooling down. placebo and aerobic + synbiotic for 12 weeks and three sessions per week. The aerobic+synbiotic and synbiotic groups also consumed one capsule with a count of 1x109 CFU) one hour after having lunch. At the end of the study, biochemical indicators were measured and evaluated. Statistical analysis was done using SPSS software, using one-way analysis of variance (ANOVA) and Bonferroni's post hoc test. Findings The present study showed that the serum levels of adropin in the group of aerobic exercise + placebo and aerobic exercise + synbiotic supplement. Also, among other findings of the current research, we can mention a significant decrease in systolic and diastolic blood pressure in the group of aerobic exercise+synbiotic supplement. serum levels of fasting glucose, insulin, insulin resistance index, BMI and body fat percentage did not show any significant difference in any of the groups. From the obtained results, it is possible to recommend the use of aerobic exercise program along with synbiotic supplement for type 2 diabetic women.