Abstarct: Abstract Background and Objectives: Type 2 diabetes leads to complications, the most important of which is diabetic neuropathy. In this complication, sensory and motor nerves are damaged and the function of peripheral nerves is impaired. The present study was performed to determine the effect of circuit resistance training on the lower limb sensory-motor nerves function in men with type 2 Diabetes and peripheral Neuropathy. materials and methods: In a randomized clinical trial, Thirty-eight men with type 2 diabetes were diagnosed with peripheral neuropathy through clinical evaluation and nerve conduction studies. They were randomly divided into experimental and control groups. Fasting blood samples before the intervention and 48 hours after the intervention, Body composition was measured and clinical evaluations and nerve conduction studies were performed. Exercise intervention including circular strength exercises with intensity equivalent to 50% of maximum repetition and 10-12 repetitions with two rounds per week were started. 1RM was measured every 4 weeks to determine the severity. In the last month, the intensity of training increased to 10-15 repetitions and 60% 1RM and three rounds per session. The intervention lasted for 12 weeks and three sessions per week. Finally, the data were analyzed using parametric statistical test including dependent and independent t-test and repeated measures analysis of variance at a significant level of P<0.05. Findings: Data analysis showed that blood glucose and hemoglobin glucose levels in the experimental group decreased significantly (P <0.05). In addition, the factors related to electrophysiological evaluations of amplitude of sensory nerves of the tibia and fine motor of the tibia and the conduction velocity of the sensory nerves of the tibia and thin of the tibia in the experimental group increased significantly compared to the pretest. In comparison between groups, only in amplitude, the potential for sensory nerve function of the tibia was not significant. There was a significant decrease in the Michigan Diabetic Neuropathy Questionnaire score. Conclusion: baxsed on the results of the present study, it can be stated that circuit Resistance training has a positive effect on controlling glucose control and levels of HbA1C and improving nerve function variables in the lower limb of the amplitude in nerve conduction velocity in type 2 diabetic patients with neuropathy.