Abstarct: Background and objectives: Diabetes is one of the most important non-communicable diseases that has had a high prevalence over the past few decades. Type II diabetes mellitus (T2DM) accounts for around 90% of all cases of diabetes and is most commonly seen in older adults. The disease changes the quality of life, reduces happiness, and general health among people with diabetes. The purpose of this study was to investigate the effect of 12 weeks of circuit resistance training on happiness, general health and glycemic control in type II diabetic men with peripheral neuropathy. Materials and methods: In a randomized clinical trial, 30 men with type II diabetic and diagnosed with peripheral neuropathy using MDNS score and nerve conduction studies were randomly assigned into experimental (61.6±7.43 years, 81.44±13.29 kg) and control groups (57.8±7.52 years, 80.84±9.01kg). Before and 48h following the experimental period, body composition measurment, blood sampling (in fasting state and 2 hours postprandial), happiness and general health questionnaires. The experimental group underwent a circuit resistance training program with 50-60 of 1RM, with the frequency of 3 sessions per week over 12 weeks. Data were analyzed using statistical tests of shapiro-wilk, repeated measure analysis of variance and Multivariate analysis of covariance at significance level of P<0.05. Results: Data analysis showed that glycosylated hemoglobin level in the experimental group significantly decreased from pre-test to post test and the changes was statistically significant compared with the control condition (P<0.05). In addition, the experimental group indicated a significant improvement in happiness and general health scale compared to the control group (P<0.05). Conclusion: baxsed on the results of the percent study, it could be concluded that 12 weeks of circuit resistance training has a favorable effect on happiness, general health and blood glucose control in type II diabetic men with peripheral neuropathy. Therefore, this exercise modality may be incorporated into the health programs of diabetics suffering from peripheral neuropathy.